An Alternative Intervention with Multiple Benefits for the Skin
In modern aesthetic surgery, mesotherapy is a medical method that is increasingly gaining popularity among both women and men for skin rejuvenation, as it represents a minimally invasive procedure.
Through this technique, various substances are injected either intraepidermally or intradermally, targeting both the face and body.
A Brief History of Mesotherapy and Its Benefits
The method was first introduced in 1952 by the French physician Michel Pistor (1924–2003) for a purpose unrelated to aesthetics. Pistor observed clinical improvement in the hearing of one of his deaf patients following multiple procaine injections around the ears. In 1958, the first official reference and definition of “mesotherapy” was published.
Since then, the technique has been widely applied in the treatment of injuries and several medical conditions, and from 1987 onwards, it has been extensively used in the field of aesthetics.
By directly targeting problem areas, the injected molecules penetrate the skin like microscopic spheres, releasing their active ingredients directly into the dermis.
Where and How Mesotherapy is Applied
As the skin ages, blood circulation gradually decreases. Consequently, oxygen and nutrient delivery is reduced, impairing the body’s ability to remove toxins. This, in turn, contributes to premature skin aging.
Mesotherapy provides a safe, minimally invasive alternative compared to more aggressive surgical techniques.
Its primary goals are to nourish and rejuvenate the skin, stimulate collagen and elastin production, and enhance skin metabolism.
Following treatment, patients report their skin feels more radiant, rested, and firm. Mesotherapy may be used as a complementary or alternative treatment to many anti-aging procedures, including botulinum toxin injections, laser resurfacing, chemical peels, antioxidant therapies, topical creams, and surgical facelifts.
It is a highly effective rejuvenation therapy for firming and tightening the skin of the face, legs, abdomen, arms, and hands.
Although women often begin treatment in their 30s, mesotherapy can achieve excellent results at any age.
Active Substances Used in Mesotherapy
The treatment is well-tolerated and generally painless. At the beginning of each session, the face is cleansed, and a topical anesthetic cream is applied to minimize discomfort.
Using very fine needles or a dermapen device, the active substances are injected into the dermis through multiple microinjections. The most commonly used agents include hyaluronic acid solutions, vitamins (especially A, E, and C), enzymes, amino acids, calcium, antioxidants, whitening agents, silicium, DMAE, and retinol.
In some cases, ready-made pharmaceutical cocktails may be used to meet the specific needs of each patient.
It is important to note that intradermal delivery of these substances ensures maximum absorption and effectiveness, far superior to topical application regardless of the richness of cosmetic formulations.
Frequency of Mesotherapy Sessions
The frequency of treatment depends on the patient’s individual skin condition and needs.
In general, 4–10 sessions are recommended, spaced 2–3 weeks apart. The patient’s age and degree of skin damage are taken into account. Younger patients may require maintenance every 8–10 months, whereas older patients typically benefit from repeat treatments every 4–6 months. Each session lasts approximately 30–40 minutes.
Possible Complications of Mesotherapy
Mesotherapy is contraindicated during pregnancy and breastfeeding.
It should also be avoided in cases of anticoagulant therapy, known allergic reactions, active skin infections, insulin-dependent diabetes, and certain autoimmune disorders (such as Hashimoto’s thyroiditis).
Complications are usually minor and transient, including localized bruising or mild erythema at the injection site, which typically resolve within a few hours.
Rarely, allergic reactions may occur to one of the injected substances. Therefore, it is crucial to inform your physician of any known sensitivities or prior allergic history before treatment.
Conclusion
Today, the plastic surgeon is the most suitable consultant for men and women who wish to maintain or enhance their appearance safely and effectively.
For any inquiries regarding mesotherapy, or any other aspect of plastic surgery, do not hesitate to contact Dr. Daskalakis, Plastic, Reconstructive and Aesthetic Surgeon.
References
- El-Domyati M, El-Ammawi TS, Medhat W, et al. (2012). Efficacy of mesotherapy for skin rejuvenation: histological and clinical study. Journal of Cosmetic Dermatology, 11(4):298–305.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513770/
- Sivagnanam G. (2010). Mesotherapy – The French connection: history and principles. Journal of Pharmacology and Pharmacotherapeutics, 1(1):4–8.
https://pubmed.ncbi.nlm.nih.gov/21808584/
- El Nazem S. (2022). Depth of Treatment in Facial Rejuvenation. PMC.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078099/
